ABSTRACT
Background: MIS-A, a hyperinflammatory condition in individual aged >21 years, is a rare condition seen in association with COVID-19 illness. Very few cases of MIS-A has been reported till date, and it still remains a box of mystery. Case Presentation: We report a case of 44 Year old male, with an evidence of prior COVID-19 illness, presented with 3 weeks of fever with polyarthralgia along with 3 days of palpitation, shortness of breath, conjunctivitis and soreness of mouth. Laboratory evidence of inflammation, features of myocarditis in 2D-Echocardiography was noted at the time of admission, with no evidence of any active infection and lung pathology. He was diagnosed as a case of MIS-A as per the CDC definition. Improvement in clinical and laboratory parameters and normalization of cardiac function was noted after treatment with IV methylprednisolone, and Intravenous Immunoglobulin. Conclusion: In adults presenting with fever and multisystem involvement, in Post-Covid period, with raised inflammatory markers, a high index of suspicion for MIS-A is required in order to start timely treatment and prevent potentially fatal outcome.